This panel brings together a dynamic lineup of representatives from Zendo Project, Fireside Project, Kosmicare, and Anashim Tovim to share concepts and case studies to their approaches to mitigate risk and harm in the psychedelic ecosystem by providing safety nets of all kinds for those embarking on profound journeys. Learn how the front lines of psychedelic harm reduction blend innovation, compassion, and scientific expertise to adapt to different demographic, geographic, and regulatory settings. To set the groundwork for a post-prohibition world we need examples of how it can be done - hear some here!