Interpreting blinded RCT data as the ultimate scientific information about psychedelics can configure epistemic injustices which drive loss of important information. Considering ancient and contemporary medicinal uses of psychedelics by many populations across the planet, with their own epistemologies and ontologies, it is time to reflect on the goal of clinical research and ponder if a purely objective approach is desirable and achievable. Beyond stand-alone drug treatments, what may be welcome is a paradigmatic shift in psychiatric research and development, carefully considering the importance of patients actively engaging with contents of non-ordinary states of consciousness through deep therapeutic alliance constituting benign unmasking.