DMT and 5-MeO-DMT are potent psychedelics known for inducing immersive experiences that surpass those of other classic psychedelics. Their rich phenomenology and historical uses are associated with experiences of "alternate realms", communication with sensed presences or "entities", near-death experiences, and profound shifts in metaphysical beliefs. We will present findings from eight years of DMT and 5-MeO-DMT research at Imperial College London, involving neuroimaging and phenomenological methods to investigate the effects of these compounds on the brain and subjective experience. The talk will also discuss preliminary findings from our latest investigations extending the DMT experience via continuous infusion. By gaining a deeper understanding of the mechanisms underlying the DMT experience, our work aims to pave the way for new therapeutic interventions and a better understanding of the nature of consciousness itself.