Join two harm reduction superheroes reflecting on the theory and practice of risk mitigation and benefit maximization. This fast-paced, forward-thinking and practical address will consider the power of mindset (set), physical and environmental conditions (setting), and the very drugs themselves (substance). Attendees will be offered novel and nuanced perspectives focused on empowering individuals to better understand the context of their drug use, ensuring safer and more intentional experiences through personal awareness and systemic change.