Substance use disorder has become a public health emergency, with the number of afflicted adults across the country jumping from twenty million in 2019 to forty million in the first year of the pandemic. Drug overdose deaths reached over 100,000 nationwide in 2020. Meanwhile, current treatment options apply counseling and behavioral therapies which have high rates of recidivism. Drawing on a long history of research, recent studies are investigating psychedelic-assisted therapy for a variety of new applications in substance use disorders. Join us to consider the role that this potential paradigm for addiction treatment may play and what it will take to confirm its efficacy.