This talk aims to show a brief overview of the archeological and historical evidence regarding the use of psilocybin mushrooms in Mesoamerica, especially among the Maya, Mixtecs, and Aztecs. This research includes the study of primary sources such as codices, ceramics, sculptures, lithic artifacts, and even colonial manuscripts in a chronological timeline to achieve a better understanding. The goal of this talk is not to provide a dogmatic truth due to the controversial character of the archeological records. Its purpose is to stimulate interpretations supported by scientific evidence and a humanistic approach. This interdisciplinary research requires the implementation of different methodologies such as iconography, historiography, and hermeneutics. This talk is part of broader research that aims to analyze, from a cross-cultural perspective, the ritual, therapeutic and philosophical uses of psychedelic mushrooms. Keywords: Psychedelic, Mushrooms, History, Archeology, Mesoamerica.